Dung's Response

Most mutations at the COL1A1 and COL1A2 results in Type I or Type IV which usually follows an autosomal dominant pedigree. This means that they can receive the allele from either parents. Mutations in CRTAP and LEPRE1 results in Type III and usually follows an autosomal recessive pedigree. This means that offsprings must receive the recessive allele from both parents.

I learned that OI has some medical advancements in improving the lives of patients with OI because we cannot control what genes are passed on from parent to offspring. Thus, we must help those that receive slightly deleterious or deleterious genes. This will enable OI patients to have equal chances of reproduction as the rest of normal people without the mutated genes.

Why does a doctor need to know evolution?
Doctors should be well aware of evolution because each individual is different from another. Since people tend to ask doctor's about their decision, doctors should be well versed in all aspects of biology and evolution is included. For example, a person that has a regular cold. The person asks the doctor if he can get antibiotics. What should the doctor say? Should he state that it is a regular cold and the immune system can easily handle it or should he prescribe him antibiotics which may mutate the bacteria and then become resistant to bacteria? As one can see, using antibiotics increases the likelihood of bacteria to becoming resistant to the drug because some bacterium cells survive and then reproduce which causes all of their offspring to have the antibiotic resistance. Therefore, it is imperative for doctors to know evolution as well because this will play a role in making decision when a patient asks for drugs for their problems.